(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one
11-oxo-mogroside V
CAS: 126105-11-1
Molecular Formula: C60H100O29
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one - Names and Identifiers
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one - Physico-chemical Properties
| Molecular Formula | C60H100O29 |
| Molar Mass | 1285.42 |
| Density | 1.51 |
| Specific Rotation(α) | (c, 0.5 in MeOH)+20.5 |
| Solubility | Soluble in water, methanol, insoluble in petroleum ether, chloroform, benzene, dichloromethane and other solvents. |
| Appearance | White crystal |
| pKa | 12.82±0.70(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD30496682 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Siraitia grosvenoris. |
| In vitro study | 11-oxo-mogroside V shows a higher scavenging effect on O 2 - (concentration at which 50% of chemiluminescence intensity is inhibited [EC 50 ]=4.79 μg/mL) and H 2 O 2 (EC 50 =16.52 μg/mL) than those of mogroside V. 11-oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC 50 =3.09 μg/mL.11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori , exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively). |
| In vivo study | In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion. |
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one - Risk and Safety
| HS Code | 29329990 |
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one - Reference
| Reference Show more | 1. Deng Shaoqian, Li Zhuangzhuang, Sun Xiaoxin, etc. Simultaneous determination of four saponins in different parts of momordica grosvenori by HPLC-MS [J]. Chinese patent medicine 2018 040(011):2486-2490. 2. [IF = 4.162] qiutingmo et al."Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin fibroblades." Drug Des Dev Ther. 2021; 15: 4901-4909 |
(3beta,9beta,10alpha,24R)-24-[(O-beta-D-Glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-6)]-beta-D-glucopyranosyl)oxy]-3-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-25-hydroxy-9-methyl-19-norlanost-5-en-11-one - Reference Information
| overview | mogroside V(Mogroside V) is a unique cucurbitane-type tetracyclic triterpene saponin in momordica grosvena. it is the main sweet ingredient in momordica grosvena. its sweetness is more than 300 times that of sucrose. it is a low-calorie, non-nutritional and non-fermented natural high-power sweetener. 11-oxo-mogroside V is also a cucurbitane-type tetracyclic triterpene saponin unique to mogrotia grosvenor, and is also a natural sweetener. In the natural plant Momordica grosvenosa, the content of 11-oxygen-mogroside V is relatively low, which is only 10% ~ 15% of the content of mogroside V. At present, the method of obtaining high content of 11-oxygen-mogroside V is to enrich and separate from mogroside extract by physical methods. |
| use | 11-oxygen-mogroside V is a cucurbitane-type tetracyclic triterpene saponin unique to mogrotia grosvenor and a natural sweetener. In the natural plant Siraitia grosvenorii, the content of 11-oxygen-Siraitia grosvenorii V is relatively low, which is only 10% ~ 15% of that of Siraitia grosvenorii V. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: anti-cancer effect, inhibition of oxidation. |
| biological activity | 11-oxo-mogroside V is a natural sweetener, isolated from Momordica grosvenori fruits of balsam pear and has strong antioxidant activity. 11-oxo-mogroside V has a significant inhibitory effect on reactive oxygen species, acting on O2-,H2O2 and * OH,EC50 is 4.79,16.52 and 146.17 μg/mL, respectively. |
| target | EC50: 4.79 μg/mL (O 2 - ), 16.52 μg/mL (H 2 O 2 ), 146.17 μg/mL (* OH) |
| in vitro study | 11-oxo-motroside v show a higher scavenging effect on O 2 - (concentration at which 50% of chemiluminescence intensity is inhibited [EC 50 ]= 4.79 μg/mL) and H 2 O 2 (EC 50=16.52 μg/mL) that of mogroside V.11-oxo-motroside v exhibits a remarkable inhibitory effect on * OH-induced DNA damage EC 50=3.09 μg/mL.11-oxo-mogroside V, A natural sweetener, isolated from the fruits of Momordica grosvenori , exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000,500 and 100 mol ratio/TPA concentration, respectively). |
| in vivo research | in the group treated with dmba, tpa and 11-oxo-mogroside v, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Momordica grosvena. |
Last Update：2024-04-10 22:30:50
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